| Date | Location | Result | |
| 12/02/21 | Warrensburg, MO | Neb.-Kearney 3, Northwest Mo. St. 2 (21-25,25-27,25-21,25-9,15-11) | Box score |
| 11/20/21 | Warrensburg, MO | Central Mo. 3, Northwest Mo. St. 2 (13-25,20-25,25-20,25-18,15-10) | Box score |
| 11/19/21 | Warrensburg, MO | Northwest Mo. St. 3, Washburn 1 (28-26,25-18,18-25,25-20) | Box score |
| 11/16/21 | Maryville, MO | Northwest Mo. St. 3, Fort Hays St. 0 (25-22,25-17,25-20) | Box score |
| 11/13/21 | Topeka, KS | Northwest Mo. St. 3, Washburn 0 (25-17,25-18,25-16) | Box score |
| 11/12/21 | Emporia, KS | Northwest Mo. St. 3, Emporia St. 0 (25-13,25-16,25-19) | Box score |
| 11/06/21 | Maryville, MO | Northwest Mo. St. 3, Newman 0 (25-16,25-13,25-19) | Box score |
| 11/05/21 | Maryville, MO | Northwest Mo. St. 3, Central Okla. 0 (25-11,25-19,25-15) | Box score |
| 11/03/21 | Maryville, MO | Northwest Mo. St. 3, Mo. Southern St. 0 (25-11,25-11,25-12) | Box score |
| 10/30/21 | Maryville, MO | Neb.-Kearney 3, Northwest Mo. St. 0 (25-15,25-21,25-18) | Box score |
| 10/29/21 | Maryville, MO | Northwest Mo. St. 3, Fort Hays St. 2 (24-26,25-17,25-13,23-25,15-12) | Box score |
| 10/26/21 | Warrensburg, MO | Central Mo. 3, Northwest Mo. St. 2 (25-22,22-25,25-20,25-27,15-9) | Box score |
| 10/23/21 | Joplin, MO | Northwest Mo. St. 3, Mo. Southern St. 0 (28-26,25-11,25-18) | Box score |
| 10/22/21 | Pittsburg, KS | Northwest Mo. St. 3, Pittsburg St. 1 (25-22,20-25,25-22,25-21) | Box score |
| 10/16/21 | Maryville, MO | Northwest Mo. St. 3, Emporia St. 0 (25-15,25-15,25-10) | Box score |
| 10/15/21 | Maryville, MO | Northwest Mo. St. 3, Washburn 2 (20-25,28-26,25-27,25-15,15-7) | Box score |
| 10/12/21 | Maryville, MO | Northwest Mo. St. 3, Missouri Western 0 (25-15,25-23,25-11) | Box score |
| 10/09/21 | Edmond, OK | Northwest Mo. St. 3, Central Okla. 2 (18-25,25-13,20-25,28-26,15-10) | Box score |
| 10/08/21 | Wichita, KS | Northwest Mo. St. 3, Newman 1 (20-25,25-21,26-24,25-17) | Box score |
| 10/02/21 | Hays, KS | Northwest Mo. St. 3, Fort Hays St. 0 (25-18,25-16,25-9) | Box score |
| 10/1/21 | Kearney, NE | Northwest Mo. St. 3, Neb.-Kearney 1 (16-25,25-22,25-17,25-22) | Box score |
| 09/25/21 | Maryville, MO | Northwest Mo. St. 3, Pittsburg St. 1 (24-26,25-16,25-16,25-20) | Box score |
| 09/18/21 | St. Joseph, MO | Northwest Mo. St. 3, Missouri Western 1 (22-25,25-13,25-10,27-25) | Box score |
| 09/17/21 | Maryville, MO | Central Mo. 3, Northwest Mo. St. 0 (25-14,25-20,25-18) | Box score |
| 09/11/21 | Springfield, IL | Northwest Mo. St. 3, Upper Iowa 1 (25-18,15-26,25-15,25-15) | Box score |
| 09/11/21 | Springfield, IL | Northwest Mo. St. 3, Purdue Northwest 0 (25-5,25-19,25-11) | Box score |
| 09/10/21 | Springfield, IL | Michigan Tech 3, Northwest Mo. St. 1 (24-26,29-27,25-21,25-19) | Box score |
| 09/10/21 | Springfield, IL | Northwest Mo. St. 3, Grand Valley St. 2 (30-32,25-19,19-25,25-22,15-12) | Box score |
| 9/4/2021 | Martinez Center | Northwest Mo. St. 3, Tampa 2 (25-23,19-25,25-14,16-25,17-15) | Box score |
| 9/4/2021 | Tampa, Fla. | Northwest Mo. St. 3, Ill.-Springfield 0 (25-16,26-24,25-21) | Box score |
| 9/3/2021 | Bob Martinez Center | Northwest Mo. St. 3, Ashland 0 (25-20,25-18,25-14) | Box score |
| 9/3/2021 | Martinez Center | Northwest Mo. St. 3, Augustana (S.D.) 1 (25-21,25-17,22-25,25-18) | Box score |