| Date | Location | Result | |
| Dec 04, 2021 | Big Rapids, Mich. | Ferris State 41, Northwest Mo. St. 20 | Box score |
| Nov 27, 2021 | Searcy, Arkansas | Northwest Mo. St. 28, Harding 9 | Box score |
| Nov 20, 2021 | Maryville, Missouri | Northwest Mo. St. 50, Central Wash. 21 | Box score |
| Nov 13, 2021 | Maryville, Missouri | Northwest Mo. St. 35, Emporia St. 7 | Box score |
| Nov 06, 2021 | Joplin, Missouri | Northwest Mo. St. 49, Mo. Southern St. 7 | Box score |
| Oct 30, 2021 | Maryville, Missouri | Northwest Mo. St. 66, Neb.-Kearney 13 | Box score |
| Oct 23, 2021 | Tahlequah, Oklahoma | Northwest Mo. St. 59, Northeastern St. 7 | Box score |
| Oct 16, 2021 | Topeka, Kansas | Washburn 17, Northwest Mo. St. 16 | Box score |
| Oct 09, 2021 | Maryville, Missouri | Northwest Mo. St. 20, Pittsburg St. 19 | Box score |
| Oct 02, 2021 | St. Joseph, Missouri | Northwest Mo. St. 30, Missouri Western 7 | Box score |
| Sep 25, 2021 | Maryville, Missouri | Northwest Mo. St. 38, Central Okla. 0 | Box score |
| Sep 18, 2021 | Warrensburg, Missour | Northwest Mo. St. 47, Central Mo. 7 | Box score |
| Sep 02, 2021 | Hays, Kansas | Northwest Mo. St. 15, Fort Hays St. 7 | Box score |